Obliviate!

This is the third entry in the Potter-themed series.

Memory Charms are best used as a last resort.

Hermione Granger famously used this in the film version of Deathly Hallows Part 1, when in a dramatic scene early in the movie, she tearfully wiped her existence from her parents' lives. In the book, she merely modified their memory, which is less permanent. 

Not nearly as heart-wrenching as seeing Hermione standing behind her parents, wand extended, whispering "Obliviate,"almost as if she wasn't going through with it. This hesitation intensified the severity of the spell and the decision that led to it.

It is not to be taken lightly. 

Hermione's hand was forced by circumstance, an act of love. The cost is hers to bear, and while we can imagine her parents' memories were restored, it won't ever be the same. 

Life sometimes makes this decision for us. In "Fantastic Beasts and Where to Find Them," the Muggle/No-maj population's memories of the events at the MACUSA were using Swooping Evil venom delivered through a thunderbird-induced rain.

Jacob Kowalski, the No-maj whisked into the midst of all the events of the film, willfully subjected himself to this memory-wiping rain, and tearfully bade goodbye to Queenie Goldstein.

In my life, I tried to wipe your memory of me, little man.

The last day I saw you, you climbed into bed, gleefully looked at me with those innocent eyes, blissfully unaware of my plan. That night, as we said goodbye, you smiled at me, gave me a hug and a wet kiss on the cheek. I did not want to let you go as you clung to me. I held you for a second longer than forever and let you go, knowing full-well in my heart that that could be the last time I would see you.

The drive home was wet. Blurry eyes did not make the trip easy. Entering a freshly empty apartment was even worse.

I suppose it's better now. That you have time to forget me. You're still very young. 

You don't know how I would have gladly given my life for you.

Yet in my mind, I imagine in the future, perhaps I will see you again.

I will admire you from afar. And maybe, as Queenie gazed at the oblivious Jacob, maybe I'll see that you'll remember parts of me, somehow.

But for now, little man, this is my sacrifice. 

Obliviate.